Time discrimination in psychosis: findings from a neuroimaging study

Introduction Previous functional neuroimaging studies have demonstrated a brain network responsible of time discrimination (TD) processes, which may play significant mediating role in other cognitive such as change detection and control. The study TD its dysfunction psychosis has become matter growing interest. We hypothesize that the impairment is involved both mechanisms deficit presented by patients. Objectives 1. To delimit regions TD. 2. examine patients diagnosed with psychosis. 3. sudy integrity white pathways 4. verify whether findings test performance predict neurocognitive profile Methods Participants included 20 (PSY group) 13 healthy controls (HC group). PSY group participants met remission criteria for 6 months prior to study. were interviewed sociodemographic information clinical assessments. They underwent detailed assesment using Measurement Treatment Research Improve Cognition Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB). Neuroimaging was performed on 3 Tesla MRI scanner. designed an experimental task including tool assess Oddbal (OD) paradigms control component. conducted under magentic resonance imaging (fMRI). used general linear model analysis individual data fMRI images random effects inference. Group differences DTI tested tract-based spatial statistics (TBSS). Results find statistically (fMRI) activity related (in HC), greater frontal cortical regions, insular cortex cerebellum. In group, functionality activation pattern networks are observed, although voxel clustering does not reach cluster significance limit when compared HC. Compared HC, fractional anisotropy (DTI) whole 21 specific regions. significantly lower scores six seven domains than well overall composite. correlated FA values groups interest MCCB scores. Image: Image 2: 3: Conclusions defined network, relationship processes more complexity. inclusion stable allowed us analyze de disfunction group. various characteristics present psychotic Disclosure Interest None Declared